Beilstein J. Org. Chem.2011,7, 1164–1172, doi:10.3762/bjoc.7.135
desired Eschenmoser coupling products were obtained within 70 s residence time. The reaction kinetics was investigated and 15 examples of different building block combinations are given.
Keywords: activation energy; episulfide; flow chemistry; ketoimine; kinetics; S-alkylation; sulfide contraction
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Graphical Abstract
Scheme 1:
Eschenmoser coupling reaction with secondary S-alkylated thioamide derivatives of type 3.